At Least I’m Getting Smarter
At some point, I decided that I was smart but unathletic, and fed on a diet of cyberpunk and the hacker ethos, I leaned into that and began to treat my body as a vestigal platform that simply served to carry my head from place to place. As it turns out, that was the stupidest thing I could do: our minds are our bodies, and a fit body creates a smart mind:
“Like synaptic plasticity, ‘neurogenesis is clearly involved in our interactions with the environment, both emotionally and cognitively,’ says neuroscientist Fred Gage of the Salk Institute in La Jolla, California… Neurons are born as blank-slate stem cells, and they go through a development process in which they need to find something to do in order to survive. Most of them don’t. It takes about twenty-eight days for a fledgling cell to plug into a network, and, as with existing neurons, Hebb’s concept of activity-dependent learning would apply: if we don’t use the newborn neurons, we lose them… ‘When we first did our experiments, we had all sorts of things going on,’ Gage explains. ‘We needed to tease that out, and to our surprise, just putting a running wheel in a cage had a profound effect on the number of cells that were born. Ironically, with running, the same percentage of cells die as in the control group - it’s just that you have a bigger starting pool. But in order for a cell to survive and integrate, it has to fire its axon.’ Exercise spawns neurons, and the stimulation of environmental enrichment helps those cells survive.
The first solid link between neurogenesis and learning came from one of Gage’s colleagues, Henrietta van Praag. They used a rodent-size pool filled with opaque water to hide a platform just beneath he surface in one quadrant. Mice don’t like water, so the equipment was designed to test how well they remember, from an earlier dip, the location of the platform - their escape route. When comparing inactive mice with others that hit the running wheel four to five kilometers a night, the results showed that the runners remembered where to find safety more quickly. Both groups swam at the same rate, but the exercised animals made a beeline for the platform, while the sedentary ones floundered about before figuring it out. When the mice were dissected, the active mice had twice as many new stem cells in the hippocampus as the inactive ones. Speaking generally about what they found, Gage says: ‘There is a significant correlation between the total number of cells and [a mouse’s] ability to perform a complex task. And if you block neurogenesis, mice can’t recall information.
Although all this research is in rodents, you can see how it might relate back to the kids in Naperville: Gym class provides the brain with the right tools to learn, and the stimulation in the kids’ classes encourages those newly developing cells to plug into the network, where they become valuable members of the signaling community…
What I find interesting, though, is that relatively few scientists are studying exercise because they’re interested in exercise. Rather, they make the mice run because it ‘massively increases neurogenesis,’ as the title of a 2006 study in Hippocampus proclaimed, and thus allows researchers to deconstruct the chain of signals behind the process. That’s what the pharmaceutical companies need to create drugs. They dream of an anti-Alzheimer’s pill that regenerates neurons to keep memory intact… Just imagine if they could put exercise in a bottle.”
– John J. Ratey, Spark: The Revolutionary New Science of Exercise and the Brain, pg. 48-50.